martes, 26 de julio de 2016

NCI Visuals Online: Image Details: Understanding the Role of Shape for Enhancing Therapeutic Delivery to Cancer by Nanotechnology

NCI Visuals Online: Image Details

National Cancer Institute



Understanding the Role of Shape for Enhancing Therapeutic Delivery to Cancer by Nanotechnology

07/25/2016 01:00 PM EDT

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Researchers at the University of North Carolina at Chapel Hill, Carolina Center of Cancer Nanotechnology Excellence (CCNE) are investigating the role of size and shape of cellular interactions with their uniquely shaped PRINT particles. Examining how cells interact with particles of differing geometries may lead to new insights about how cells internalize synthetic materials and how rational design of shape can be applied for the more efficient delivery of therapeutics by nanoscale materials. The image set shown here is of a cell interacting with a 'helicopter' shaped particle.

NCI Visuals Online: Image Details: Tumor-Associated Macrophages with Fluorescent Nanoparticles

NCI Visuals Online: Image Details

National Cancer Institute

Tumor-Associated Macrophages with Fluorescent Nanoparticles

07/25/2016 01:00 PM EDT

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Researchers at the MIT-Harvard Center of Cancer Nanotechnology Excellence (CCNE) have found that tumor-associated macrophages play key roles in tumor progression and during treatment. The intravital microscope image comes from a live mouse and displays tumor cells (in green from their expression of a fluorescent protein) surrounded by tumor macrophages (in red from a targeted fluorescent 25nm nanoparticle to track their location over time). The blue represents the tumor vasculature.

NCI Visuals Online: Image Details: Quantum Dots to Generate Higher Sensitivity Sensors for Cancer Applications

NCI Visuals Online: Image Details

National Cancer Institute

Quantum Dots to Generate Higher Sensitivity Sensors for Cancer Applications

07/25/2016 01:00 PM EDT



Researchers at Emory University are developing the next generation of quantum dots for use as highly sensitive fluorescent sensors to detect cancer. This image is a transmission electron micrograph of quantum dot nanocrystals composed of a cadmium mercury telluride alloy core with several layers of zinc sulfide acting as a shell. These quantums dots are unique because the optical and electronic properties can be finely tuned by altering the composition of the ternary alloy core, a much more facile process than previous generations, without changing the particle size.

NCI Visuals Online: Image Details: Novel Tissue Mimetics that Help Evaluate Nanoparticle Delivery

NCI Visuals Online: Image Details

National Cancer Institute

07/25/2016 01:00 PM EDT

Novel Tissue Mimetics that Help Evaluate Nanoparticle Delivery

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The focus of the Northeastern University's CCNE is to develop promising nanoparticles for lung, ovarian, and pancreatic cancer. In this image, researchers explored the phenotypic changes occurring in tumor cells using 3D spheroid models to evaluate nanoparticle-based delivery. The green fluorescense in this image comes from live cells while the red comes from dead cells and was obtained from a confocal fluorescense microscope.

NCI Visuals Online: Image Details: Novel Multimodality Imaging Approaches to Target Metastatic Cancers

NCI Visuals Online: Image Details

National Cancer Institute

07/25/2016 01:00 PM EDT

Novel Multimodality Imaging Approaches to Target Metastatic Cancers

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The Center of Cancer Nanotechnology Excellence at Johns Hopkins University is focused on nanotechnology-based in vitro assays, targeted chemotherapy, and immunotherapy for lung and pancreatic cancers. Utilizing their metastatic model of melanoma, the image shown here is a fusion of lung (CAT scan, in solid yellow) and their molecular-genetic imaging technique that highlights the metastatic lesions (SPECT image, covering from blue-to-red that correlates lesion density).

NCI Visuals Online: Image Details: Enabling Novel X-ray Sources to Deliver Tumor-Killing Radiation

NCI Visuals Online: Image Details

National Cancer Institute

Enabling Novel X-ray Sources to Deliver Tumor-Killing Radiation

07/25/2016 01:00 PM EDT



Physicists and physicians at the Carolina Center of Cancer Nanotechnology Excellence (CCNE) are creating a new approach to the treatment of aggressive tumors. Tiny beams of X-ray radiation are generated using an array of carbon nanotube X-ray sources to deliver tumor-killing radiation, while preserving normal tissue. The micrograph demonstrates this technology as it shows a 250 micron wide section of tissue damage that was initiated by this X-ray source.

NCI Visuals Online: Image Details: Developing Novel Vaccine Delivery Systems for Cancer Therapy

NCI Visuals Online: Image Details

National Cancer Institute

Developing Novel Vaccine Delivery Systems for Cancer Therapy

07/25/2016 01:00 PM EDT

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Researchers at the Texas Center for Cancer Nanomedicine (TCCN) are working on the devlopment of nano-vaccines for cancer therapy. In this research, bone marrow cells were stimulated with cytokines (signaling molecules used extensively in intercellular communication) to favor differentiation into antigen presenting cells, known as dendritic cells. These dendritic cells are then presented with the nano-vaccines (as shown in this image), which are porous silicon particle discs loaded with immune stimulating molecules and tumor antigens. These now activated cells are then injected back into the host to stimulate an anti-tumor response.