domingo, 30 de diciembre de 2012

PLOS ONE: Meta-Analysis of 125 Rheumatoid Arthritis-Related Single Nucleotide Polymorphisms Studied in the Past Two Decades

PLOS ONE: Meta-Analysis of 125 Rheumatoid Arthritis-Related Single Nucleotide Polymorphisms Studied in the Past Two Decades

Research Article

Meta-Analysis of 125 Rheumatoid Arthritis-Related Single Nucleotide Polymorphisms Studied in the Past Two Decades

  • Yongshuai Jiang equal contributor,
  • Ruijie Zhang equal contributor mail,
  • Jiajia Zheng equal contributor,
  • Panpan Liu equal contributor,
  • Guoping Tang equal contributor,
  • Hongchao Lv,
  • Lanying Zhang,
  • Zhenwei Shang,
  • Yuanbo Zhan,
  • Wenhua Lv,
  • Miao Shi,
  • Ruimin Zhang mail

Abstract

Objective

Candidate gene association studies and genome-wide association studies (GWAs) have identified a large number of single nucleotide polymorphisms (SNPs) loci affecting susceptibility to rheumatoid arthritis (RA). However, for the same locus, some studies have yielded inconsistent results. To assess all the available evidence for association, we performed a meta-analysis on previously published case-control studies investigating the association between SNPs and RA.

Methods

Two hundred and sixteen studies, involving 125 SNPs, were reviewed. For each SNP, three genetic models were considered: the allele, dominant and recessive effects models. For each model, the effect summary odds ratio (OR) and 95% CIs were calculated. Cochran’s Q-statistics were used to assess heterogeneity. If the heterogeneity was high, a random effects model was used for meta-analysis, otherwise a fixed effects model was used.

Results

The meta-analysis results showed that: (1) 30, 28 and 26 SNPs were significantly associated with RA (P<0 .01=".01" all="all" allele="allele" and="and" association="association" dominant="dominant" em="em" for="for" models:="models:" models="models" recessive="recessive" respectively.="respectively." rs2476601="rs2476601" showed="showed" strongest="strongest" the="the" three="three">OR
= 1.605, 95% CI: 1.540–1.672, P<1 .00e=".00e" em="em" for="for" t-allele="t-allele" the="the">OR = 1.638, 95% CI: 1.565–1.714, P<1 .00e=".00e" and="and" em="em" for="for" genotype="genotype" t="t" the="the">OR = 2.544, 95% CI: 2.173–2.978, P<1.00E−15 for the T/T genotype. (3) Only 23 (18.4%), 13 (10.4%) and 15 (12.0%) SNPs had high heterogeneity (P<0 .01=".01" a="a" according="according" and="and" are="are" associations="associations" been="been" bias.="bias." bias="bias" egger="egger" few="few" for="for" funnel="funnel" have="have" in="in" loci="loci" may="may" models="models" more="more" no="no" of="of" on="on" only="only" other="other" p="p" plots="plots" publication="publication" regression="regression" required.="required." respectively.="respectively." s="s" snps="snps" some="some" studies="studies" subject="subject" tested="tested" tests="tests" the="the" there="there" these="these" three="three" to="to" was="was" were="were">

Conclusion

Our meta-analysis provides a comprehensive evaluation of the RA association studies from the past two decades. The detailed meta-analysis results are available at: http://210.46.85.180/DRAP/index.php/Meta​analysis/index.

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