jueves, 30 de abril de 2015

Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients

Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients



Sci Transl Med
Vol. 7, Issue 285, p. 285ra64 
Sci. Transl. Med. DOI: 10.1126/scitranslmed.3010825
  • RESEARCH ARTICLE
BIOENGINEERING

Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients

  1. Glenn E. Green8,*
+Author Affiliations
  1. 1Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
  2. 2Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
  3. 3Department of Pediatrics, Division of Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
  4. 4Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.
  5. 5Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, UT 84132, USA.
  6. 6Department of Pediatric Otolaryngology, Children’s Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
  7. 7Department of Cardiac Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
  8. 8Department of Otolaryngology-Head and Neck Surgery, Division of Pediatric Otolaryngology, University of Michigan, Ann Arbor, MI 48109, USA.
  1. *Corresponding author. E-mail: gegreen@med.umich.edu

Abstract

Three-dimensional (3D) printing offers the potential for rapid customization of medical devices. The advent of 3D-printable biomaterials has created the potential for device control in the fourth dimension: 3D-printed objects that exhibit a designed shape change under tissue growth and resorption conditions over time. Tracheobronchomalacia (TBM) is a condition of excessive collapse of the airways during respiration that can lead to life-threatening cardiopulmonary arrests. We demonstrate the successful application of 3D printing technology to produce a personalized medical device for treatment of TBM, designed to accommodate airway growth while preventing external compression over a predetermined time period before bioresorption. We implanted patient-specific 3D-printed external airway splints in three infants with severe TBM. At the time of publication, these infants no longer exhibited life-threatening airway disease and had demonstrated resolution of both pulmonary and extrapulmonary complications of their TBM. Long-term data show continued growth of the primary airways. This process has broad application for medical manufacturing of patient-specific 3D-printed devices that adjust to tissue growth through designed mechanical and degradation behaviors over time.
Citation: R. J. Morrison, S. J. Hollister, M. F. Niedner, M. G. Mahani, A. H. Park, D. K. Mehta, R. G. Ohye, G. E. Green, Mitigation of tracheobronchomalacia with 3D-printed personalized medical devices in pediatric patients. Sci. Transl. Med. 7285ra64 (2015).


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